Pathology practices face unique billing challenges: complex panel tests, reflex/add-on coding, specimen tracking, and tight payer rules. That’s why many labs and pathology groups turn to specialist pathology billing companies for reliable revenue capture and compliance. In this list of leading pathology billing companies, you’ll find firms that deliver focused pathology expertise, LIS integration, and analytics to speed payments and reduce denials. If your lab is evaluating pathology billing outsourcing companies, this roundup highlights options that handle the specialty’s nuances so clinicians can focus on diagnostics and care.
Quick Glance Comparison Table of the Top-Rated Pathology Billing Companies in USA
Here’s a list of the Top 10 Pathology Billing Companies. We’ll explain what each one does, highlight its expertise, and show why it’s a smart choice for the healthcare practices, labs, and clinics in USA that need faster, more accurate payments.
MedCare MSO delivers specialized pathology medical billing services. It manages the dual coding needs of anatomic and clinical pathology while supporting CLIA compliance and MIPS reporting. Their proprietary Maximus platform integrates with LIS systems to automate charge capture, claims submission, payment posting, and analytics. Certified coders (CPC, CCS) handle appeals and A/R follow-up, with a strong focus on correct modifier use, molecular and immunohistochemistry coding, and real-time insurance verification to prevent front-end rejections and maintain HIPAA/CLIA compliance.
Experience: 13+ Years
Location: United States
MedCare MSO reports measurable results that set it apart among pathology billing companies. Their expertise has reduced denials for practices from 22% to 5%, increased cash flow by up to 35%, and achieved 98.5%+ clean claim rates. They also report a reduction in days-in-A/R from about 42 days to roughly 25–30 days. These improvements are driven by multi-level claim scrubbing, targeted appeals, continuous LIS integration, MIPS support, and structured denial-code workflows.
Work with billing experts who understand your specialty-specific rules, payer requirements, and documentation standards to accelerate reimbursements and reduce revenue leakage.
MBC offers end-to-end RCM and specialty billing across 30+ specialties, including pathology, with capabilities from charge entry to A/R recovery. Their site highlights large-scale experience claims processed, charts coded, and an AI+human approach to improve accuracy and collections.
Experience: 14 Years
Location: USA
As one of the broader pathology billing companies, MBC combines automation and experienced billers to drive measurable uplifts. They promote revenue-boosting case studies and volume statistics. That blend of technology plus specialized practice teams helps pathology providers reduce denials and speed turnaround on complex laboratory claims.
Invensis presents a comprehensive pathology billing services offering from charge capture, coding (clinical/anatomical pathology), and LIS integration to denial management, AR follow-up, and compliance audits. They claim industry metrics, including 95% billing accuracy and major improvements in turnaround times and revenue cycle efficiency.
Experience: 19 Years
Location: USA
Invensis positions itself as a global pathology billing outsourcing company that achieves high accuracy (95%) and big operational wins (reported 70% improvement in RCM efficiency, faster turnaround). For labs seeking an outsourcing partner with large delivery teams and measurable KPIs, Invensis is designed to scale.
iCareBilling is an EHR-agnostic medical billing and credentialing firm that highlights compatibility with any EHR and a 94% first-pass claim rate for clean submissions, features that matter when pathology labs integrate LIS data with billing systems.
Experience: 7 Years
Location: USA
iCareBilling stands out among pathology billing companies because of its EHR/EMR interoperability and emphasis on clean claim submissions. For pathology billing services, interoperability reduces manual handoffs between LIS and billing platforms and helps keep turnaround times low.
Medusind offers pathology-specific RCM with over 20 years of pathology experience, certified pathology coders, and claims paid typically in under 40 days; their site lists large volumes managed and technology built for pathology organizations.
Experience: 23 Years
Location: USA
Medusind ranks among the leading pathology billing companies because it pairs specialized coding teams, pathology-tuned software, and analytics that achieve measurable gains (improved collections, fewer days in A/R, and higher net collection rates). Their pathology dashboards and dedicated teams give labs visibility into specimen-level and payer performance.
Apple Billing offers full-service medical billing, credentialing, provider enrollment, and eligibility verification, core functions that support accurate pathology claim submission and payer access. Their site lists fast operational SLAs (e.g., charges/ERAs posted within hours) and multi-specialty support that includes lab and pathology services.
Experience: 6 Years
Location: USA
Apple Billing positions itself as a practical partner among pathology billing companies by combining credentialing and enrollment expertise with fast claim follow-up and denials followed within 24 hours, a useful model for pathology groups that need both payer access and timely collections. Their clear SLAs and reporting help labs track progress and reduce administrative lag.
1st Choice offers multi-decade experience in medical billing and revenue cycle management across several specialties. Their site emphasizes consultative engagement, free consultations, practice reviews, and a mix of technology adoption and hands-on billing services.
Experience: 13 Years
Location: USA
For pathology practices vetting pathology billing companies, 1st Choice’s long experience and bespoke consulting approach can be valuable, especially for smaller labs that want a partner to analyze current workflows, plug revenue leaks, and gradually migrate complex pathology billing tasks to a managed process.
APS specializes in pathology, laboratory, and radiology billing and has operated since 1960; its site highlights deep domain expertise, white papers focused on pathology issues, and event participation in pathology societies.
Experience: 25 Years
Location: USA
As a focused pathology-and-lab billing firm, APS is one of the industry’s dedicated pathology billing companies: decades of experience mean their teams understand specimen-level workflows, payer nuances, and lab-specific compliance, all of which support fewer denials and stronger reimbursement for pathology groups.
Health Prime’s pathology practice page lays out EMR-agnostic RCM tools for pathology, accession number tracking, advanced coding logic for layered CPT/ICD modifiers, and MIPS consulting tailored to diagnostic groups. Their site stresses analytics and specimen-level business intelligence.
Experience: 22 Years
Location: USA
Health Prime distinguishes itself among pathology billing companies through deep analytics and purpose-built pathology automation, charge capture across LIS and EMR, and specimen volume KPIs. That technology focus helps pathology groups reduce denials, forecast staffing, and improve payer performance tracking.
It is a U.S.-based medical billing company that offers end-to-end revenue cycle management (RCM) for practices of all sizes. Their services include medical billing, coding (ICD-10/CPT), credentialing, denial management, AR recovery, audits/consulting, and 24/7 claim submission and follow-up. The firm promotes scale and experience, noting they’ve processed 15,000+ claims and support 15,000+ providers, and emphasize HIPAA-compliant workflows, detailed performance reporting, and specialty-tailored RCM solutions.
Experience: 1 Years
Location: USA
This company highlights measurable operational strengths: a claimed 99% clean claim rate and advanced denial-management processes that speed reimbursements and reduce rework. They position themselves as a practical outsourcing partner by offering dedicated account managers, free practice audits, customizable pricing, and fast credentialing to improve payer access. For practices seeking a single vendor to handle billing, coding, credentialing and AR recovery, their combination of high clean-claim performance and round-the-clock follow-up is the key differentiator.
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Choosing the best pathology billing companies in the USA starts with checking their pathology-specific expertise, including experience with anatomic and clinical pathology coding. Look for companies that understand CLIA compliance, modifier usage, and molecular pathology billing, as these directly impact reimbursements. Strong LIS and EHR integration is essential to reduce manual errors and speed up claims processing. Evaluate their denial management and A/R follow-up performance, especially clean claim rates and days in A/R. Transparency in reporting, analytics, and KPIs helps you track financial health. Also, confirm certified coders, HIPAA compliance, and data security standards. Finally, choose pathology billing companies that offer scalable services, clear SLAs, and proven results aligned with your lab’s size and growth goals.
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