List of ICD 10 CM Code Updates for FY 2026

October 1st, 2025, came and went, and with it came the annual FY 2026 ICD 10 CM code updates. Hundreds of codes got added, deleted, or changed, and if you’re still billing the way you did earlier, those claims are being rejected.

Some practices adopted these updates easily, but plenty are dealing with claim denials they didn’t expect. The difference usually comes down to knowing what actually changed and acting on it quickly. In this article, we’ll cover every single ICD 10 CM code change for FY 2026. By the end of it, you will know exactly what’s different from last year and what you need to do to keep your revenue stable.

FY 2026 ICD 10 CM Code Updates Summary

The Centers for Medicare & Medicaid Services (CMS) released the FY 2026 ICD-10-CM updates in June 2025, effective October 1st, 2025, onwards. Here’s what changed:

New Codes 487
Revised Codes 38
Deleted Codes 28

CHAPTER 1: CERTAIN INFECTIOUS AND PARASITIC DISEASES (A00-B99)

New Infectious Diseases ICD 10 CM Codes

B88.01 – Infestation by Demodex mites

B88.09 – Other acariasis

Instructional Note Changes

B18 Chronic viral hepatitis

B88.0 Other acariasis

Revisions

B96.21 – Shiga toxin-producing Escherichia coli [E. coli] [STEC] O157 as the cause of diseases classified elsewhere

B96.22 – Other specified Shiga toxin-producing Escherichia coli [E. coli] [STEC] as the cause of diseases classified elsewhere

CHAPTER 2: NEOPLASMS (C00-D49)

New ICD 10 CM Codes for Inflammatory Breast Cancer

C50.A – Malignant inflammatory neoplasm of breast (parent code)

C50.A0 – Malignant inflammatory neoplasm of unspecified breast

C50.A1 – Malignant inflammatory neoplasm of right breast

C50.A2 – Malignant inflammatory neoplasm of left breast

Revisions

C7B.04 – Secondary carcinoid tumors of peritoneum

C77 – Secondary and unspecified malignant neoplasm of lymph nodes

D12.6 – Benign neoplasm of colon, unspecified

D48.11 – Desmoid tumor

CHAPTER 3: DISEASES OF THE BLOOD AND BLOOD-FORMING ORGANS (D50-D89)

New ICD 10 CM Codes - Functional Disorders of Neutrophils

D71.1 – Leukocyte adhesion deficiency

D71.8 – Other functional disorders of polymorphonuclear neutrophils

D71.9 – Functional disorders of polymorphonuclear neutrophils, unspecified

Deletions

D71 – Previously contained terms now redistributed to D71.1, D71.8, and D71.9

Excludes Changes

D53.8 – Other specified nutritional anemias

D68.312 – Antiphospholipid antibody with hemorrhagic disorder

D68.61 – Antiphospholipid syndrome

D68.62 – Lupus anticoagulant syndrome

CHAPTER 4: ENDOCRINE, NUTRITIONAL AND METABOLIC DISEASES (E00-E89)

New ICD 10 CM Codes - Diabetes in Remission

E11.A – Type 2 diabetes mellitus without complications in remission

E11.9 – Type 2 diabetes mellitus without complications

New ICD 10 CM Codes - Hyperoxaluria

E72.530 – Primary hyperoxaluria, type 1

E72.538 – Other specified primary hyperoxaluria

E72.539 – Primary hyperoxaluria, unspecified

E72.540 – Dietary hyperoxaluria

E72.541 – Enteric hyperoxaluria

E72.548 – Other secondary hyperoxaluria

E72.549 – Secondary hyperoxaluria, unspecified

New ICD 10 CM Codes - Familial Hypercholesterolemia

E78.010 – Homozygous familial hypercholesterolemia [HoFH]

E78.011 – Heterozygous familial hypercholesterolemia [HeFH]

E78.019 – Familial hypercholesterolemia, unspecified

New ICD 10 CM Codes - Pyrophosphate Metabolism Disorders

E83.820 – Generalized arterial calcification of infancy with unspecified genetic causality

Code also, if applicable, associated conditions such as:

E83.821 – ENPP1 deficiency causing generalized arterial calcification of infancy

Code also, if applicable, associated conditions such as:

E83.822 – ENPP1 deficiency causing autosomal recessive hypophosphatemic rickets type 2

E83.823 – ABCC6 deficiency causing generalized arterial calcification of infancy

Code also, if applicable, associated conditions such as:

E83.824 – ABCC6 deficiency causing pseudoxanthoma elasticum

E83.825 – CD73 deficiency causing arterial calcification

New ICD 10 CM Codes - Lipodystrophy

E88.10 – Lipodystrophy, unspecified

E88.11 – Partial lipodystrophy

E88.12 – Generalized lipodystrophy

E88.13 – Localized lipodystrophy

E88.14 – HIV-associated lipodystrophy

E88.19 – Other lipodystrophy, not elsewhere classified

Instructional Note Changes

E27.5 – Adrenomedullary hyperfunction

NEW Code also, if applicable:

E71.540 – Rhizomelic chondrodysplasia punctata

E72.53 – Primary hyperoxaluria

E83.3 – Disorders of phosphorus metabolism and phosphatases

E88.02 – Plasminogen deficiency

E88.1 – Lipodystrophy, not elsewhere classified

E88.43 – Disorders of mitochondrial tRNA synthetases

NEW inclusions:

NEW Code also, if applicable: leukoencephalopathy (G93.49)

CHAPTER 5: MENTAL, BEHAVIORAL AND NEURODEVELOPMENTAL DISORDERS (F01-F99)

Revisions

F02 – Dementia in other diseases classified elsewhere

F42 – Obsessive-compulsive disorder

F48.2 – Pseudobulbar affect

F63.2 – Kleptomania

CHAPTER 6: DISEASES OF THE NERVOUS SYSTEM (G00-G99)

New ICD 10 CM Codes - Multiple Sclerosis Subtypes

G35.A – Relapsing-remitting multiple sclerosis

G35.B0 – Primary progressive multiple sclerosis, unspecified

G35.B1 – Active primary progressive multiple sclerosis

G35.B2 – Non-active primary progressive multiple sclerosis

G35.C0 – Secondary progressive multiple sclerosis, unspecified

G35.C1 – Active secondary progressive multiple sclerosis

G35.C2 – Non-active secondary progressive multiple sclerosis

G35.D – Multiple sclerosis, unspecified

New ICD 10 CM Codes - Other Nervous System Conditions

G31.87 – Primary progressive apraxia of speech

G71.036 – Limb girdle muscular dystrophy due to fukutin related protein dysfunction

Deletions

G35 – Multiple sclerosis (old code)

DELETED terms:

G71.038 – Other limb girdle muscular dystrophy

DELETED terms:

Revisions and Additions

G00.1 – Pneumococcal meningitis

G04 – Encephalitis, myelitis and encephalomyelitis

G23.3 – Hypomyelination with atrophy of the basal ganglia and cerebellum

G37.3 – Acute transverse myelitis in demyelinating disease of central nervous system

G37.9 – Demyelinating disease of central nervous system, unspecified

G89 – Pain, not elsewhere classified

CHAPTER 7: DISEASES OF THE EYE AND ADNEXA (H00-H59)

New ICD 10 CM Codes - Eyelid Inflammation

H01.81 – Other specified inflammation of right upper eyelid

H01.82 – Other specified inflammation of right lower eyelid

H01.83 – Other specified inflammation of right eye, unspecified eyelid

H01.84 – Other specified inflammation of left upper eyelid

H01.85 – Other specified inflammation of left lower eyelid

H01.86 – Other specified inflammation of left eye, unspecified eyelid

H01.89 – Other specified inflammation of unspecified eye, unspecified eyelid

H01.8A – Other specified inflammation of right eye, upper and lower eyelids

H01.8B – Other specified inflammation of left eye, upper and lower eyelids

New ICD 10 CM Codes - Thyroid Orbitopathy

H05.831 – Thyroid orbitopathy, right orbit

H05.832 – Thyroid orbitopathy, left orbit

H05.833 – Thyroid orbitopathy, bilateral

H05.839 – Thyroid orbitopathy, unspecified orbit

H05.83 – Thyroid orbitopathy (parent code)

  • Graves’ ophthalmopathy
  • Graves’ orbitopathy
  • Thyroid eye disease
  • Code also, if applicable, any associated conditions such as:
    • autoimmune thyroiditis (E06.3)
    • thyrotoxicosis with diffuse goiter (E05.0-)

New ICD 10 CM Codes - Neovascular Glaucoma

H40.841 – Neovascular secondary angle closure glaucoma, right eye

H40.842 – Neovascular secondary angle closure glaucoma, left eye

H40.843 – Neovascular secondary angle closure glaucoma, bilateral

H40.849 – Neovascular secondary angle closure glaucoma, unspecified eye

H40.84 – Neovascular secondary angle closure glaucoma (parent code)

  • Code first the underlying condition such as:
    • central retinal vein occlusion (H34.81)
    • diabetes mellitus (E08.39, E09.39, E10.39, E11.39, E13.39)
    • retinal ischemia (H35.82)

Instructional Note Changes

H01.8 – Other specified inflammations of eyelid

H33.3 – Retinal breaks without detachment

H35.4 – Peripheral retinal degeneration

H42 – Glaucoma in diseases classified elsewhere

H53.03 – Strabismic amblyopia

CHAPTER 9: DISEASES OF THE CIRCULATORY SYSTEM (I00-I99)

New ICD 10 CM Codes - Fontan Related Circulation

I27.840 – Fontan-associated liver disease [FALD]

I27.841 – Fontan-associated lymphatic dysfunction

  • Code also associated conditions such as:
    • chylothorax (J94.0)
    • Fontan associated protein-losing enteropathy (K90.89)
    • plastic (obstructive) bronchitis (J44.89)

I27.848 – Other Fontan-associated condition

I27.849 – Fontan related circulation, unspecified

I27.84 – Fontan related circulation (parent code)

Instructional Note Changes

I51 – Complications and ill-defined descriptions of heart disease

  • DELETED from Excludes1, MOVED to Excludes2:
    • any condition in I51.4-I51.9 due to hypertension (I11.-)
    • any condition in I51.4-I51.9 due to hypertension and chronic kidney disease (I13.-)
    • heart disease specified as rheumatic (I00-I09)

I51.5 – Myocardial degeneration

  • NEW Excludes1:
    • myocardial degeneration due to hypertension (I11.-)
    • myocardial degeneration due to hypertension and chronic kidney disease (I13.-)

I51.7 – Cardiomegaly

  • NEW Excludes1:
    • cardiomegaly due to hypertension (I11.-)
    • cardiomegaly due to hypertension and chronic kidney disease (I13.-)

I70.9 – Other and unspecified atherosclerosis

I80 – Phlebitis and thrombophlebitis

CHAPTER 10: DISEASES OF THE RESPIRATORY SYSTEM (J00-J99)

Revisions

J20 – Acute bronchitis

J40 – Bronchitis, not specified as acute or chronic

J43 – Emphysema

J44 – Other chronic obstructive pulmonary disease

  • Changed: Excludes1 → Excludes2 for:
    • chronic bronchitis NOS (J42)
    • chronic simple and mucopurulent bronchitis (J41.-)
    • chronic tracheitis (J42)
    • chronic tracheobronchitis (J42)

J84.1 – Other interstitial pulmonary diseases with fibrosis

CHAPTER 11: DISEASES OF THE DIGESTIVE SYSTEM (K00-K95)

New Terms/Additions

K75.81 – Nonalcoholic steatohepatitis (NASH)

K76.0 – Fatty (change of) liver, not elsewhere classified

CHAPTER 12: DISEASES OF THE SKIN AND SUBCUTANEOUS TISSUE (L00-L99)

New ICD 10 CM Codes - Flank Injuries

L02.217 – Cutaneous abscess of flank

L02.227 – Furuncle of flank

L03.31A – Cellulitis of flank

L03.32A – Acute lymphangitis of flank

New ICD 10 CM Codes - Non-Pressure Chronic Ulcers

Abdomen

L98.431 – Non-pressure chronic ulcer of abdomen limited to breakdown of skin

L98.432 – Non-pressure chronic ulcer of abdomen with fat layer exposed

L98.433 – Non-pressure chronic ulcer of abdomen with necrosis of muscle

L98.434 – Non-pressure chronic ulcer of abdomen with necrosis of bone

L98.435 – Non-pressure chronic ulcer of abdomen with muscle involvement without evidence of necrosis

L98.436 – Non-pressure chronic ulcer of abdomen with bone involvement without evidence of necrosis

L98.438 – Non-pressure chronic ulcer of abdomen with other specified severity

L98.439 – Non-pressure chronic ulcer of abdomen with unspecified severity

Chest

L98.441 – Non-pressure chronic ulcer of chest limited to breakdown of skin

L98.442 – Non-pressure chronic ulcer of chest with fat layer exposed

L98.443 – Non-pressure chronic ulcer of chest with necrosis of muscle

L98.444 – Non-pressure chronic ulcer of chest with necrosis of bone

L98.445 – Non-pressure chronic ulcer of chest with muscle involvement without evidence of necrosis

L98.446 – Non-pressure chronic ulcer of chest with bone involvement without evidence of necrosis

L98.448 – Non-pressure chronic ulcer of chest with other specified severity

L98.449 – Non-pressure chronic ulcer of chest with unspecified severity

Neck

L98.451 – Non-pressure chronic ulcer of neck limited to breakdown of skin

L98.452 – Non-pressure chronic ulcer of neck with fat layer exposed

L98.453 – Non-pressure chronic ulcer of neck with necrosis of muscle

L98.454 – Non-pressure chronic ulcer of neck with necrosis of bone

L98.455 – Non-pressure chronic ulcer of neck with muscle involvement without evidence of necrosis

L98.456 – Non-pressure chronic ulcer of neck with bone involvement without evidence of necrosis

L98.458 – Non-pressure chronic ulcer of neck with other specified severity

L98.459 – Non-pressure chronic ulcer of neck with unspecified severity

Face

L98.461 – Non-pressure chronic ulcer of face limited to breakdown of skin

L98.462 – Non-pressure chronic ulcer of face with fat layer exposed

L98.463 – Non-pressure chronic ulcer of face with necrosis of muscle

L98.464 – Non-pressure chronic ulcer of face with necrosis of bone

L98.465 – Non-pressure chronic ulcer of face with muscle involvement without evidence of necrosis

L98.466 – Non-pressure chronic ulcer of face with bone involvement without evidence of necrosis

L98.468 – Non-pressure chronic ulcer of face with other specified severity

L98.469 – Non-pressure chronic ulcer of face with unspecified severity

Groin

L98.471 – Non-pressure chronic ulcer of groin limited to breakdown of skin

L98.472 – Non-pressure chronic ulcer of groin with fat layer exposed

L98.473 – Non-pressure chronic ulcer of groin with necrosis of muscle

L98.474 – Non-pressure chronic ulcer of groin with necrosis of bone

L98.475 – Non-pressure chronic ulcer of groin with muscle involvement without evidence of necrosis

L98.476 – Non-pressure chronic ulcer of groin with bone involvement without evidence of necrosis

L98.478 – Non-pressure chronic ulcer of groin with other specified severity

L98.479 – Non-pressure chronic ulcer of groin with unspecified severity

Upper Limb - Right Upper Arm

L98.A111 – Non-pressure chronic ulcer of right upper arm limited to breakdown of skin

L98.A112 – Non-pressure chronic ulcer of right upper arm with fat layer exposed

L98.A113 – Non-pressure chronic ulcer of right upper arm with necrosis of muscle

L98.A114 – Non-pressure chronic ulcer of right upper arm with necrosis of bone

L98.A115 – Non-pressure chronic ulcer of right upper arm with muscle involvement without evidence of necrosis

L98.A116 – Non-pressure chronic ulcer of right upper arm with bone involvement without evidence of necrosis

L98.A118 – Non-pressure chronic ulcer of right upper arm with other specified severity

L98.A119 – Non-pressure chronic ulcer of right upper arm with unspecified severity

Upper Limb - Left Upper Arm

L98.A121 – Non-pressure chronic ulcer of left upper arm limited to breakdown of skin

L98.A122 – Non-pressure chronic ulcer of left upper arm with fat layer exposed

L98.A123 – Non-pressure chronic ulcer of left upper arm with necrosis of muscle

L98.A124 – Non-pressure chronic ulcer of left upper arm with necrosis of bone

L98.A125 – Non-pressure chronic ulcer of left upper arm with muscle involvement without evidence of necrosis

L98.A126 – Non-pressure chronic ulcer of left upper arm with bone involvement without evidence of necrosis

L98.A128 – Non-pressure chronic ulcer of left upper arm with other specified severity

L98.A129 – Non-pressure chronic ulcer of left upper arm with unspecified severity

Upper Limb - Unspecified Upper Arm

L98.A191 – Non-pressure chronic ulcer of unspecified upper arm limited to breakdown of skin

L98.A192 – Non-pressure chronic ulcer of unspecified upper arm with fat layer exposed

L98.A193 – Non-pressure chronic ulcer of unspecified upper arm with necrosis of muscle

L98.A194 – Non-pressure chronic ulcer of unspecified upper arm with necrosis of bone

L98.A195 – Non-pressure chronic ulcer of unspecified upper arm with muscle involvement without evidence of necrosis

L98.A196 – Non-pressure chronic ulcer of unspecified upper arm with bone involvement without evidence of necrosis

L98.A198 – Non-pressure chronic ulcer of unspecified upper arm with other specified severity

L98.A199 – Non-pressure chronic ulcer of unspecified upper arm with unspecified severity

Upper Limb - Right Forearm

L98.A211 – Non-pressure chronic ulcer of right forearm limited to breakdown of skin

L98.A212 – Non-pressure chronic ulcer of right forearm with fat layer exposed

L98.A213 – Non-pressure chronic ulcer of right forearm with necrosis of muscle

L98.A214 – Non-pressure chronic ulcer of right forearm with necrosis of bone

L98.A215 – Non-pressure chronic ulcer of right forearm with muscle involvement without evidence of necrosis

L98.A216 – Non-pressure chronic ulcer of right forearm with bone involvement without evidence of necrosis

L98.A218 – Non-pressure chronic ulcer of right forearm with other specified severity

L98.A219 – Non-pressure chronic ulcer of right forearm with unspecified severity

Upper Limb - Left Forearm

L98.A221 – Non-pressure chronic ulcer of left forearm limited to breakdown of skin

L98.A222 – Non-pressure chronic ulcer of left forearm with fat layer exposed

L98.A223 – Non-pressure chronic ulcer of left forearm with necrosis of muscle

L98.A224 – Non-pressure chronic ulcer of left forearm with necrosis of bone

L98.A225 – Non-pressure chronic ulcer of left forearm with muscle involvement without evidence of necrosis

L98.A226 – Non-pressure chronic ulcer of left forearm with bone involvement without evidence of necrosis

L98.A228 – Non-pressure chronic ulcer of left forearm with other specified severity

L98.A229 – Non-pressure chronic ulcer of left forearm with unspecified severity

Upper Limb - Unspecified Forearm

L98.A291 – Non-pressure chronic ulcer of unspecified forearm limited to breakdown of skin

L98.A292 – Non-pressure chronic ulcer of unspecified forearm with fat layer exposed

L98.A293 – Non-pressure chronic ulcer of unspecified forearm with necrosis of muscle

L98.A294 – Non-pressure chronic ulcer of unspecified forearm with necrosis of bone

L98.A295 – Non-pressure chronic ulcer of unspecified forearm with muscle involvement without evidence of necrosis

L98.A296 – Non-pressure chronic ulcer of unspecified forearm with bone involvement without evidence of necrosis

L98.A298 – Non-pressure chronic ulcer of unspecified forearm with other specified severity

L98.A299 – Non-pressure chronic ulcer of unspecified forearm with unspecified severity

Upper Limb - Right Hand

L98.A311 – Non-pressure chronic ulcer of right hand limited to breakdown of skin

L98.A312 – Non-pressure chronic ulcer of right hand with fat layer exposed

L98.A313 – Non-pressure chronic ulcer of right hand with necrosis of muscle

L98.A314 – Non-pressure chronic ulcer of right hand with necrosis of bone

L98.A315 – Non-pressure chronic ulcer of right hand with muscle involvement without evidence of necrosis

L98.A316 – Non-pressure chronic ulcer of right hand with bone involvement without evidence of necrosis

L98.A318 – Non-pressure chronic ulcer of right hand with other specified severity

L98.A319 – Non-pressure chronic ulcer of right hand with unspecified severity

Upper Limb - Left Hand

L98.A321 – Non-pressure chronic ulcer of left hand limited to breakdown of skin

L98.A322 – Non-pressure chronic ulcer of left hand with fat layer exposed

L98.A323 – Non-pressure chronic ulcer of left hand with necrosis of muscle

L98.A324 – Non-pressure chronic ulcer of left hand with necrosis of bone

L98.A325 – Non-pressure chronic ulcer of left hand with muscle involvement without evidence of necrosis

L98.A326 – Non-pressure chronic ulcer of left hand with bone involvement without evidence of necrosis

L98.A328 – Non-pressure chronic ulcer of left hand with other specified severity

L98.A329 – Non-pressure chronic ulcer of left hand with unspecified severity

Upper Limb - Unspecified Hand

L98.A391 – Non-pressure chronic ulcer of unspecified hand limited to breakdown of skin

L98.A392 – Non-pressure chronic ulcer of unspecified hand with fat layer exposed

L98.A393 – Non-pressure chronic ulcer of unspecified hand with necrosis of muscle

L98.A394 – Non-pressure chronic ulcer of unspecified hand with necrosis of bone

L98.A395 – Non-pressure chronic ulcer of unspecified hand with muscle involvement without evidence of necrosis

L98.A396 – Non-pressure chronic ulcer of unspecified hand with bone involvement without evidence of necrosis

L98.A398 – Non-pressure chronic ulcer of unspecified hand with other specified severity

L98.A399 – Non-pressure chronic ulcer of unspecified hand with unspecified severity

Revisions

L02.212 – Cutaneous abscess of back

L02.222 – Furuncle of back

L51 – Erythema multiforme

L97.2 – Non-pressure chronic ulcer of calf

Excludes Changes

Dermatitis and eczema (L20-L30) section

CHAPTER 13: DISEASES OF THE MUSCULOSKELETAL SYSTEM (M00-M99)

New Codes

M05.A – Abnormal rheumatoid factor and anti-citrullinated protein antibody with rheumatoid arthritis

Revisions

M21.159 – Varus deformity, not elsewhere classified, unspecified

M24.076 – Loose body in unspecified toe joints

M61.129 – Myositis ossificans progressiva, unspecified arm

Instructional Note Changes

M36.3 – Arthropathy in other blood disorders

  • NEW Code first underlying disease, such as:
    • disease of blood and blood-forming organs, unspecified (D75.9)
    • other hemoglobinopathies (D58.2)
    • thalassemia (D56.-)

CHAPTER 14: DISEASES OF THE GENITOURINARY SYSTEM (N00-N99)

New ICD 10 CM Codes for Membranoproliferative Glomerulonephritis

N00.B1 – Acute nephritic syndrome with idiopathic immune membranoproliferative glomerulonephritis (IC-MPGN)

N00.B2 – Acute nephritic syndrome with secondary immune complex membranoproliferative glomerulonephritis (IC-MPGN)

N04.B1 – Nephrotic syndrome with idiopathic immune complex membranoproliferative glomerulonephritis (IC-MPGN)

N04.B2 – Nephrotic syndrome with secondary immune complex membranoproliferative glomerulonephritis (IC-MPGN)

New ICD 10 CM Codes for Hereditary Nephropathy

N07.B – Hereditary nephropathy, not elsewhere classified with APOL1-mediated kidney disease [AMKD]

Deletions

N00.5 – Acute nephritic syndrome with diffuse mesangiocapillary glomerulonephritis

N04.5 – Nephrotic syndrome with diffuse mesangiocapillary glomerulonephritis

Revisions

N61 – Inflammatory disorders of breast

N85.A – Isthmocele

CHAPTER 15: PREGNANCY, CHILDBIRTH AND THE PUERPERIUM (O00-O9A)

Revisions

O70.1 – Second degree perineal laceration during delivery

O70.4 – Anal sphincter tear complicating delivery, not associated with third degree laceration

O90.4 – Postpartum acute kidney failure

CHAPTER 16: CERTAIN CONDITIONS ORIGINATING IN THE PERINATAL PERIOD (P00-P96)

Revisions

P09.6 – Abnormal findings on neonatal screening

CHAPTER 17: CONGENITAL MALFORMATIONS, DEFORMATIONS, CHROMOSOMAL ABNORMALITIES, AND GENETIC DISORDERS (Q00-QA0)

Chapter Title Change

Revised from: Congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) Revised to: Congenital malformations, deformations, chromosomal abnormalities, and genetic disorders (Q00-QA0)

New Block Added

QA0 – Genetic disorders, not elsewhere classified

New ICD 10 CM Codes for Genetic Syndromes

Q87.87 – Hao-Fountain Syndrome

  • HAFOUS
  • Use Additional code, if applicable, for associated conditions such as:
    • autism spectrum disorder (F84.0)
    • developmental speech disorder (F80.-)
    • epilepsy, by specific type (G40.-)
    • intellectual disabilities (F70-F79)
    • pervasive developmental disorders (F84.-)

Q87.88 – CTNNB1 syndrome

  • Use Additional code, if applicable, for associated conditions such as:
    • cerebral palsy (G80.-)
    • congenital heart malformations (Q20.0-Q24.9)
    • developmental disorder of speech and language (F80.-)
    • exudative retinopathy (H35.02-)
    • intellectual disability (F70-F79)
    • microcephaly (Q02)

Q89.81 – Kabuki syndrome

New ICD 10 CM Codes for Usher Syndrome

Q99.811 – Usher syndrome, type 1

Q99.812 – Usher syndrome, type 2

Q99.813 – Usher syndrome, type 3

Q99.818 – Other Usher syndrome

Q99.819 – Usher syndrome, unspecified

Q99.81 – Usher syndrome (parent code)

New ICD 10 CM Codes for Neurodevelopmental Disorders (QA0 Section)

QA0.0101 – SCN2A-related neurodevelopmental disorder

QA0.0102 – CACNA1A-related neurodevelopmental disorder

QA0.0109 – Neurodevelopmental disorder related to pathogenic variant in other ion channel gene

QA0.0131 – SLC6A1-related disorder

QA0.0139 – Neurodevelopmental disorder, related to pathogenic variant in other transporter or solute carrier gene

QA0.0141 – Syntaxin-binding protein 1-related disorder

QA0.0142 – DLG4-related synaptopathy

QA0.0149 – Neurodevelopmental disorder, related to pathogenic variant in other synapse related gene

QA0.0151 – FOXG1 syndrome

QA0.0159 – Neurodevelopmental disorder, related to other genes associated with transcription and gene expression

QA0.8 – Other neurodevelopmental disorders related to pathogenic variants in other specific genes

Revisions

Q75.00 – Craniosynostosis

Q75.001Revised from: Craniosynostosis unspecified, unilateral

Q75.002Revised from: Craniosynostosis unspecified, bilateral

Q75.009Revised from: Craniosynostosis unspecified

Q75.02 – Coronal craniosynostosis

Q75.021Revised from: Coronal craniosynostosis unilateral

Q75.022Revised from: Coronal craniosynostosis bilateral

Q75.029Revised from: Coronal craniosynostosis unspecified

Q77.3 – Chondrodysplasia punctata

Instructional Note Changes

Q28.8 – Other specified congenital malformations of circulatory system

Q82.8 – Other specified congenital malformations of skin

CHAPTER 18: SYMPTOMS, SIGNS AND ABNORMAL CLINICAL AND LABORATORY FINDINGS (R00-R99)

New ICD 10 CM Codes for Pelvic and Perineal Pain

R10.20 – Pelvic and perineal pain unspecified side

R10.21 – Pelvic and perineal pain right side

R10.22 – Pelvic and perineal pain left side

R10.23 – Pelvic and perineal pain bilateral

R10.24 – Suprapubic pain

New ICD 10 CM Codes for Flank Pain and Tenderness

R10.A0 – Flank pain, unspecified side

R10.A1 – Flank pain, right side

R10.A2 – Flank pain, left side

R10.A3 – Flank pain, bilateral

R10.A – Pain localized to flank (parent code)

R10.8A1 – Right flank tenderness

R10.8A2 – Left flank tenderness

R10.8A3 – Suprapubic tenderness

R10.8A9 – Flank tenderness, unspecified

R10.85 – Abdominal pain of multiple sites

  • Excludes1:
    • abdominal rigidity NOS (R19.3)
    • generalized abdominal pain associated with acute abdomen (R10.0)
    • generalized abdominal pain NOS (R10.84)
    • localized abdominal pain (R10.1-R10.4-)

New ICD 10 CM Codes for Costovertebral Tenderness

R39.851 – Costovertebral (angle) tenderness, right side

R39.852 – Costovertebral (angle) tenderness, left side

R39.853 – Costovertebral (angle) tenderness, bilateral

R39.859 – Costovertebral (angle) tenderness, unspecified side

R39.85 – Costovertebral (angle) tenderness (parent code)

New ICD 10 CM Codes for Cannabis Hyperemesis Syndrome

R11.16 – Cannabis hyperemesis syndrome

  • Cannabinoid hyperemesis syndrome
  • Code also:
    • cannabis abuse (F12.1-)
    • cannabis dependence (F12.2-)
    • cannabis use, unspecified (F12.92-, F12.93, F12.95-, F12.98-, F12.99)
    • manifestations, such as:
      • dehydration (E86.0)
      • electrolyte imbalance (E87.8)

New ICD 10 CM Codes for Abnormal Immunological Findings

R76.81 – Abnormal rheumatoid factor and anti-citrullinated protein antibody without rheumatoid arthritis

R76.89 – Other specified abnormal immunological findings in serum

Instructional Note Changes

R10 – Abdominal and pelvic pain

R10.1 – Pain localized to upper abdomen

  • NEW Excludes2:
    • pain localized to flank (R10.A-)
    • pelvic and perineal pain (R10.2-)

R10.2 – Pelvic and perineal pain

  • NEW Excludes2:
    • pain localized to other parts of lower abdomen (R10.3-)
    • pain localized to upper abdomen (R10.1-)

R10.3 – Pain localized to other parts of lower abdomen

  • NEW Excludes2:
    • pain localized to flank (R10.A-)
    • pelvic and perineal pain (R10.2-)

R10.81 – Abdominal tenderness

  • NEW Excludes2:
    • pain localized to other parts of lower abdomen (R10.3-)
    • pain localized to upper abdomen (R10.1-)

R10.82 – Rebound abdominal tenderness

  • NEW Excludes2:
    • pain localized to other parts of lower abdomen (R10.3-)
    • pain localized to upper abdomen (R10.1-)

R15.0 – Incomplete defecation

  • Changed: Excludes1 → Excludes2:
    • constipation (K59.0-)
    • fecal impaction (K56.41)

R39.12 – Poor urinary stream

R40.1 – Stupor

R40.2A – Nontraumatic coma due to underlying condition

  • NEW Excludes1:
    • coma scale, best motor response (R40.24.-)
    • coma scale, best verbal response (R40.22.-)
    • coma scale, eyes open (R40.21.-)
    • Glasgow coma scale, total score (R40.23.-)

R52 – Pain, unspecified

R53.8 – Other malaise and fatigue

R62.51 – Failure to thrive (child)

R65.21 – Severe sepsis with septic shock

R69 – Illness, unspecified

R76.8 – Other specified abnormal immunological findings in serum

R82.992 – Hyperoxaluria

  • Excludes1 revised to:
    • primary hyperoxaluria (E72.53-) [was E72.53]
    • secondary hyperoxaluria (E72.54-)

R87.619 – Unspecified abnormal cytological findings in specimens from cervix uteri

CHAPTER 19: INJURY, POISONING AND CERTAIN OTHER CONSEQUENCES OF EXTERNAL CAUSES (S00-T88)

New ICD 10 CM Codes for Flank Injuries (Extensive - Showing Pattern)

Contusions

S30.11 – Contusion of abdominal wall

S30.12 – Contusion of groin

S30.13 – Contusion of flank (latus) region

Abrasions

S30.81A – Abrasion of flank

Blisters

S30.82A – Blister (nonthermal) of flank

External Constriction

S30.84A – External constriction of flank

Superficial Foreign Body

S30.85A – Superficial foreign body of flank

Insect Bites

S30.86A – Insect bite (nonvenomous) of flank

Other Superficial Bites

S30.87A – Other superficial bite of flank

Unspecified Superficial Injury

S30.9A – Unspecified superficial injury of flank

Open Wounds Without Penetration - Right Flank

S31.106 – Unspecified open wound of abdominal wall, right flank without penetration into peritoneal cavity

S31.116 – Laceration without foreign body of abdominal wall, right flank without penetration into peritoneal cavity

S31.126 – Laceration with foreign body of abdominal wall, right flank without penetration into peritoneal cavity

S31.136 – Puncture wound of abdominal wall without foreign body, right flank without penetration into peritoneal cavity

S31.146 – Puncture wound of abdominal wall with foreign body, right flank without penetration into peritoneal cavity

S31.156 – Open bite of abdominal wall, right flank without penetration into peritoneal cavity

Open Wounds Without Penetration - Left Flank

S31.107 – Unspecified open wound of abdominal wall, left flank without penetration into peritoneal cavity

S31.117 – Laceration without foreign body of abdominal wall, left flank without penetration into peritoneal cavity

S31.127 – Laceration with foreign body of abdominal wall, left flank without penetration into peritoneal cavity

S31.137 – Puncture wound of abdominal wall without foreign body, left flank without penetration into peritoneal cavity

S31.147 – Puncture wound of abdominal wall with foreign body, left flank without penetration into peritoneal cavity

S31.157 – Open bite of abdominal wall, left flank without penetration into peritoneal cavity

Open Wounds Without Penetration - Unspecified Flank

S31.10A – Unspecified open wound of abdominal wall, unspecified flank without penetration into peritoneal cavity

S31.11A – Laceration without foreign body of abdominal wall, unspecified flank without penetration into peritoneal cavity

S31.12A – Laceration with foreign body of abdominal wall unspecified flank without penetration into peritoneal cavity

S31.13A – Puncture wound of abdominal wall without foreign body, unspecified flank without penetration into peritoneal cavity

S31.14A – Puncture wound of abdominal wall with foreign body, unspecified flank without penetration into peritoneal cavity

S31.15A – Open bite of abdominal wall, unspecified flank without penetration into peritoneal cavity

Open Wounds With Penetration - Right Flank

S31.606 – Unspecified open wound of abdominal wall, right flank with penetration into peritoneal cavity

S31.616 – Laceration without foreign body of abdominal wall, right flank with penetration into peritoneal cavity

S31.626 – Laceration with foreign body of abdominal wall, right flank with penetration into peritoneal cavity

S31.636 – Puncture wound of abdominal wall without foreign body, right flank with penetration into peritoneal cavity

S31.646 – Puncture wound of abdominal wall with foreign body, right flank with penetration into peritoneal cavity

S31.656 – Open bite of abdominal wall, right flank with penetration into peritoneal cavity

Open Wounds With Penetration - Left Flank

S31.607 – Unspecified open wound of abdominal wall, left flank with penetration into peritoneal cavity

S31.617 – Laceration without foreign body of abdominal wall, left flank with penetration into peritoneal cavity

S31.627 – Laceration with foreign body of abdominal wall, left flank with penetration into peritoneal cavity

S31.637 – Puncture wound of abdominal wall without foreign body, left flank with penetration into peritoneal cavity

S31.647 – Puncture wound of abdominal wall with foreign body, left flank with penetration into peritoneal cavity

S31.657 – Open bite of abdominal wall, left flank with penetration into peritoneal cavity

Open Wounds With Penetration - Unspecified Flank

S31.60A – Unspecified open wound of abdominal wall, unspecified flank with penetration into peritoneal cavity

S31.61A – Laceration without foreign body of abdominal wall, unspecified flank with penetration into peritoneal cavity

S31.62A – Laceration with foreign body of abdominal wall, unspecified flank with penetration into peritoneal cavity

S31.63A – Puncture wound of abdominal wall without foreign body, unspecified flank with penetration into peritoneal cavity

S31.64A – Puncture wound of abdominal wall with foreign body, unspecified flank with penetration into peritoneal cavity

S31.65A – Open bite of abdominal wall, unspecified flank with penetration into peritoneal cavity

New ICD 10 CM Codes for Fluoroquinolone Poisoning

T36.AX1 – Poisoning by fluoroquinolone antibiotics, accidental (unintentional)

T36.AX2 – Poisoning by fluoroquinolone antibiotics, intentional self-harm

T36.AX3 – Poisoning by fluoroquinolone antibiotics, assault

T36.AX4 – Poisoning by fluoroquinolone antibiotics, undetermined

T36.AX5 – Adverse effect of fluoroquinolone antibiotics

T36.AX6 – Underdosing of fluoroquinolone antibiotics

New ICD 10 CM Codes for Xylazine Toxicity

T65.841 – Toxic effect of xylazine, accidental (unintentional)

T65.842 – Toxic effect of xylazine, intentional self-harm

T65.843 – Toxic effect of xylazine, assault

T65.844 – Toxic effect of xylazine, undetermined

T65.84 – Toxic effect of xylazine (parent code)

  • Use Additional code(s) for all associated manifestations, such as:
    • cellulitis and acute lymphangitis (L03.-)
    • cutaneous abscess, furuncle and carbuncle (L02.-)
    • non-pressure chronic ulcer of lower limb, not elsewhere classified (L97.-)
    • non-pressure chronic ulcer of skin, not elsewhere classified (L98.4-)

New ICD 10 CM Codes for War Theater Effects

T75.830 – Gulf war illness

T75.838 – Effects of other war theater

T75.83 – Effects of war theater (parent code)

New ICD 10 CM Codes for Milk Allergy with Baked Milk Tolerance

T78.070 – Anaphylactic reaction due to milk and dairy products with tolerance to baked milk

T78.071 – Anaphylactic reaction due to milk and dairy products with reactivity to baked milk

T78.079 – Anaphylactic reaction due to milk and dairy products, unspecified

New ICD 10 CM Codes for Egg Allergy with Baked Egg Tolerance

T78.080 – Anaphylactic reaction due to egg with tolerance to baked egg

T78.081 – Anaphylactic reaction due to egg with reactivity to baked egg

T78.089 – Anaphylactic reaction due to eggs, unspecified

New ICD 10 CM Codes for Other Adverse Food Reactions

T78.110 – Other adverse food reactions due to milk and dairy products with tolerance to baked milk

T78.111 – Other adverse food reaction due to milk and dairy products with reactivity to baked milk

T78.119 – Other adverse food reaction due to milk and dairy products with baked milk tolerance/reactivity, unspecified

T78.120 – Other adverse food reaction due to egg with tolerance to baked egg

T78.121 – Other adverse food reaction due to egg with reactivity to baked egg

T78.129 – Other adverse food reaction due to egg with baked egg tolerance/reactivity, unspecified

T78.19 – Other adverse food reactions, not elsewhere classified

Revisions

S12.8 – Fracture of other parts of neck

S30.1 – Contusion of abdominal wall

S37.6 – Injury of uterus

S62.9 – Unspecified fracture

S62.90Revised from: Unspecified fracture of unspecified wrist and hand

S62.91Revised from: Unspecified fracture of right wrist and hand

S62.92Revised from: Unspecified fracture of left wrist and hand

S74.21 – Injury of cutaneous sensory nerve at hip and thigh level, right leg

CHAPTER 20: EXTERNAL CAUSES OF MORBIDITY (V00-Y99)

New ICD 10 CM Codes for Blast Overpressure

War Operations

Y36.A1 – Low level blast overpressure in war operations

Y36.A2 – High level blast overpressure in war operations

Y36.A – Blast overpressure in war operations (parent code)

  • Code also type of explosive, if known:
    • accidental detonation of onboard munitions (Y36.140)
    • explosion of grenade (Y36.290)
    • explosion of torpedo (Y36.040)
    • improvised explosive device (Y36.230)

Military Operations

Y37.A1 – Low level blast overpressure in military operations

Y37.A2 – High level blast overpressure in military operations

Y37.A – Blast overpressure in military operations (parent code)

  • Code also type of explosive, if known:
    • accidental detonation of onboard munitions (Y37.140)
    • explosion of grenade (Y37.290)
    • explosion of torpedo (Y37.040)
    • improvised explosive device (Y37.230)

New ICD 10 CM Codes for Activity Codes

Y93.L1 – Activity, splitting wood

Y93.L9 – Activity, other outdoor activity

New ICD 10 CM Codes for Foreign Body Entry

W44.H9 – Other sharp object entering into or through a natural orifice

W45.3 – Fishing hook entering through skin

Revisions

V06.938 – Pedestrian on other standing micro-mobility pedestrian conveyance injured in collision with other nonmotor vehicle

W44.A9 – Other batteries entering into or through a natural orifice

Y07.435 – Stepbrother, perpetrator of maltreatment and neglect

CHAPTER 21: FACTORS INFLUENCING HEALTH STATUS AND CONTACT WITH HEALTH SERVICES (Z00-Z99)

New ICD 10 CM Codes for Genetic Susceptibility

Z15.05 – Genetic susceptibility to malignant neoplasm of fallopian tube(s)

Z15.060 – Genetic susceptibility to colorectal cancer

Z15.068 – Genetic susceptibility to other malignant neoplasm of digestive system

Z15.07 – Genetic susceptibility to malignant neoplasm of urinary tract

Z15.3 – Genetic susceptibility to kidney disease

New ICD 10 CM Codes for Prophylactic Surgery

Z40.81 – Encounter for prophylactic surgery for removal of ovary(s) for persons without known genetic/familial risk factors

Z40.82 – Encounter for prophylactic surgery for removal of fallopian tube(s) for persons without known genetic/familial risk factors

Z40.89 – Encounter for other prophylactic surgery

New ICD 10 CM Codes for Employment Issues

Z56.6 – Other physical and mental strain related to work

Z56.89 – Other problems related to employment

  • NEW inclusions:
    • Furloughed
    • Underemployed

New ICD 10 CM Codes for Housing and Economic Issues

Z59.02 – Unsheltered homelessness

Z59.12 – Inadequate housing utilities

Z59.19 – Other inadequate housing

Z59.861 – Financial insecurity, difficulty paying for utilities

Z59.868 – Other specified financial insecurity

Z59.869 – Financial insecurity, unspecified

New ICD 10 CM Codes for War Theater Exposure

Z77.31 – Contact with and (suspected) exposure to Gulf War theater

Z77.39 – Contact with and (suspected) exposure to other war theater

New ICD 10 CM Codes for Family History

Z80.44 – Family history of malignant neoplasm of fallopian tube(s)

Z84.11 – Family history of APOL1-mediated kidney disease [AMKD]

Z84.19 – Family history of other disorders of kidney and ureter

Z84.A – Family history of exposure to diethylstilbestrol

New ICD 10 CM Codes for Personal History

Z85.4A – Personal history of malignant neoplasm of fallopian tube(s)

Z86.00A – Personal history of in-situ neoplasm of the fallopian tube(s)

New ICD 10 CM Codes for Allergy to Milk with Baked Milk Tolerance

Z91.0110 – Allergy to milk products, unspecified

Z91.0111 – Allergy to milk products with tolerance to baked milk

Z91.0112 – Allergy to milk products with reactivity to baked milk

New ICD 10 CM Codes for Allergy to Eggs with Baked Egg Tolerance

Z91.0120 – Allergy to eggs, unspecified

Z91.0121 – Allergy to eggs with tolerance to baked egg

Z91.0122 – Allergy to eggs with reactivity to baked egg

New ICD 10 CM Codes for DES Exposure

Z91.B – Personal risk factor of exposure to diethylstilbestrol

  • DES daughter or son
  • Personal risk factor of exposure to DES
  • Personal risk factor of exposure to DES in utero
  • Second generation DES exposure
  • Code also, associated conditions, such as:
    • conditions classifiable to C50.-
    • osteoporosis (M80.-)
    • premature menopause (E28.31-)

Instructional Note Changes

Z00-Z13 – Persons encountering health services for examinations

Z01 – Encounter for other special examination without complaint

Z40.0 – Encounter for prophylactic surgery for risk factors related to malignant neoplasms

Z40.02 – Encounter for prophylactic removal of ovary(s)

Z59.819 – Housing instability, housed unspecified

Z59.86 – Financial insecurity

Z59.87 – Material hardship due to limited financial resources, not elsewhere classified

Z83.718 – Family history of other colon polyps

Z87.41 – Personal history of dysplasia of the female genital tract

Z98 – Other postprocedural states

Z99.11 – Dependence on respirator [ventilator] status

How to Access Complete Code Files

CMS Website: https://www.cms.gov/medicare/coding-billing/icd-10-codes

Download These Files:

  1. 2026 ICD-10-CM Addendum (ZIP file containing):
    • Table 6A: New diagnosis codes
    • Table 6C: Invalid/deleted diagnosis codes
    • Table 6E: Revised diagnosis codes
  2. 2026 ICD-10-CM Guidelines (PDF)

2026 ICD-10-CM Code Descriptions in Tabular Order

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